Across TCGA patient cohorts, GLRA4 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRA4-associated genes across cancer lineages are Caspase-7-cleavedD198, NF-kB-p65_pS536, and TIGAR. Each is linked with GLRA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLRA4-to-partner and partner-to-GLRA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRA4→partner) and Y-score (partner→GLRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.483	+1.827	.019	.015	3	3
UCEC	NF-kB-p65_pS536 →	-0.344	-2.321	.029	.033	3	2
UCEC	TIGAR →	+0.136	+1.807	.009	.025	3	2
UCEC	eIF4E →	+0.165	+3.335	.023	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.353	+1.594	.045	.042	3	1
UCEC	JNK_pT183_Y185 →	-0.181	-2.321	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

GLRA4 survival (RNA) · tumor vs normal (RNA) · all GLRA4 data types