Across TCGA pan-cancer cohorts, GLRA4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GLRA4’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where GLRA4 RNA is repressed in tumor relative to normal tissue. In most cancer types GLRA4 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.
COAD, BRCA, and BLCA are the cancer types where GLRA4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLRA4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.