GLRA2

Across TCGA cell cohorts, GLRA2 mutation is significantly associated with the mutation status of many other genes, with 1,571 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLRA2-associated genes across cancer lineages are PEX5L, ASTN2, and PCDHGA3. Each is linked with GLRA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLRA2-to-partner and partner-to-GLRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEX5L grouped by GLRA2-low versus GLRA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRA2→partner) and Y-score (partner→GLRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PEX5L →	+5.053	+4.239	.007	.007	1	3
SKIN	ASTN2 →	+3.053	+3.718	.006	.006	1	3
SKIN	PCDHGA3 →	+4.638	+4.638	<.001	<.001	1	3
SKIN	SH3BP2 →	+5.053	+4.239	.007	.007	1	2
LARGE_INTESTINE	RAPGEF4 →	+3.215	+3.954	<.001	<.001	1	2
LUNG_NSCLC_LUAD	FGFR2 →	+3.924	+5.063	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,571 associations by consensus.

PEX5L by GLRA2 expression — SKIN

Explore this box plot interactively →