GLRA2

Across TCGA pan-cancer cohorts, GLRA2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GLRA2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GLRA2 RNA is repressed in tumor relative to normal tissue. In most cancer types GLRA2 is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

KICH, HNSC, and READ are the cancer types where GLRA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLRA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−0.085	.022	3	view →
HNSC	All	III,IV	+0.015	.009	3	view →
READ	All	All	−1.106	.018	2	view →
COAD	Male	III,IV	−0.626	.012	2	view →
LUSC	All	All	+0.093	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GLRA2–KICH

Open the KICH breakdown →