GLP1R

Across TCGA cell cohorts, GLP1R mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLP1R-associated genes across cancer lineages are APCS, TSGA10IP, and BPIFB3. Each is linked with GLP1R in more than 1 cancer types. Because this analysis shows association rather than direction, both GLP1R-to-partner and partner-to-GLP1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APCS grouped by GLP1R-low versus GLP1R-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLP1R→partner) and Y-score (partner→GLP1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	APCS →	+0.060	+3.345	<.001	.007	3	1
SKIN	TSGA10IP →	+0.173	+3.533	<.001	.007	3	1
SKIN	BPIFB3 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TTLL8 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR52H1 →	+0.040	+4.347	<.001	.001	3	1
LARGE_INTESTINE	TRDN →	+0.046	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

APCS by GLP1R expression — SKIN

Explore this box plot interactively →