GLIS3

Across TCGA patient cohorts, GLIS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,078 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GLIS3-associated proteins across cancer lineages are TLN2, MMP2, and PPFIBP1_S434. Each is linked with GLIS3 in more than 5 cancer types. Because this analysis shows association rather than direction, both GLIS3-to-partner and partner-to-GLIS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLIS3 versus TLN2 in BRCA, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIS3→partner) and Y-score (partner→GLIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.486	+0.809	<.001	<.001	3	6
BRCA	MMP2 →	+0.789	+0.838	<.001	<.001	3	6
BRCA	PPFIBP1_S434 →	+0.580	+0.718	<.001	<.001	3	5
OV	SEC23A →	+0.368	+0.940	<.001	.007	3	5
BRCA	TIMP2 →	+0.698	+0.746	<.001	<.001	3	5
LSCC	TRIO →	+0.337	+0.592	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,078 associations by consensus.

GLIS3 vs TLN2 — BRCA

Explore this scatter interactively →