GLIS3-AS1

Across TCGA pan-cancer cohorts, GLIS3-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GLIS3-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GLIS3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GLIS3-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRC, HNSC, and BRCA are the cancer types where GLIS3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.538	0.671	.002	66	view →
HNSC	DFS	Median	IV	0.723	0.560	.001	51	view →
BRCA	DFS	Quartile	III,IV	0.774	0.915	<.001	50	view →
UCEC	DFS	Quartile	II,III,IV	0.229	0.724	.005	36	view →
COAD	OS	Median	IV	0.228	0.859	.001	29	view →
THYM	OS	Tertile	All	0.708	1.000	.001	25	view →
KIRP	DFS	Tertile	All	0.784	0.895	.016	24	view →
SKCM	OS	Tertile	IV	0.811	0.179	.004	21	view →
LIHC	DFS	Median	III,IV	0.291	0.133	.018	17	view →
MESO	DFS	Quartile	All	0.759	0.179	.006	12	view →
UCS	DFS	Tertile	IV	0.885	0.381	.024	12	view →
STAD	DFS	Tertile	IV	0.101	0.501	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GLIS3-AS1–KIRC (OS)

Open the KIRC breakdown →