GLIS3-AS1

Across TCGA pan-cancer cohorts, GLIS3-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GLIS3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GLIS3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types GLIS3-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where GLIS3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLIS3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.787	<.001	12	view →
KICH	Female	All	−1.125	<.001	10	view →
KIRP	All	III,IV	−0.580	<.001	7	view →
LUSC	Male	II,III,IV	−0.723	<.001	4	view →
CHOL	All	All	+0.516	.002	4	view →
BRCA	Female	All	+0.105	.015	4	view →
ESCA	All	II,III,IV	+0.565	.021	2	view →
BLCA	All	All	+0.207	.028	2	view →
THCA	All	All	+0.391	.031	1	view →
STAD	All	All	+0.287	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GLIS3-AS1–KIRC

Open the KIRC breakdown →