GLIPR1

Across TCGA patient cohorts, GLIPR1 mutation is significantly associated with the RNA expression of many other genes, with 1,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLIPR1-associated genes across cancer lineages are CASTOR2, RN7SL248P, and UHRF1. Each is linked with GLIPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLIPR1-to-partner and partner-to-GLIPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASTOR2 grouped by GLIPR1-low versus GLIPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLIPR1→partner) and Y-score (partner→GLIPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CASTOR2 →	+0.893	+2.491	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.088	+3.652	<.001	<.001	3	2
UCEC	UHRF1 →	+1.053	+2.917	<.001	<.001	3	2
BLCA	RNU6-25P →	+0.533	+3.937	.002	.007	3	2
CESC	MTCYBP45 →	+0.219	+4.934	<.001	.002	3	2
SKCM	PES1 →	+0.517	+3.491	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,812 associations by consensus.

CASTOR2 by GLIPR1 expression — UCEC

Explore this box plot interactively →