GLI2

Across TCGA patient cohorts, GLI2 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,622 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GLI2-associated proteins across cancer lineages are SERPINF1, SORBS3, and CD248. Each is linked with GLI2 in more than 7 cancer types. Because this analysis shows association rather than direction, both GLI2-to-partner and partner-to-GLI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI2 versus SERPINF1 in OV, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI2→partner) and Y-score (partner→GLI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINF1 →	+0.919	+0.860	<.001	.001	3	8
UCEC	SORBS3 →	+0.561	+0.480	<.001	<.001	3	8
OV	CD248 →	+0.796	+0.752	<.001	<.001	3	8
PDAC	EFEMP2 →	+0.715	+0.727	<.001	<.001	3	8
OV	GLI2_S1014 →	+1.171	+0.759	<.001	.003	3	8
UCEC	SARM1 →	+0.508	+0.684	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,622 associations by consensus.

GLI2 vs SERPINF1 — OV

Explore this scatter interactively →