GLI2

Across TCGA patient cohorts, GLI2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,267 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GLI2-associated genes across cancer lineages are SELL, CLDN24, and SLC48A1. Each is linked with GLI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLI2-to-partner and partner-to-GLI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GLI2 versus SELL in UCEC, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI2→partner) and Y-score (partner→GLI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SELL →	-1.507	-0.808	.007	.002	3	2
HNSC	CLDN24 →	-2.334	-0.835	.002	<.001	3	2
HNSC	SLC48A1 →	+0.699	+0.654	.009	.004	3	2
LSCC	ELFN1 →	+0.724	+0.416	.005	.006	3	2
HNSC	EDIL3-DT →	+1.432	+0.661	.001	.008	3	2
HNSC	MIR4650-1 →	-2.123	-0.781	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,267 associations by consensus.

GLI2 vs SELL — UCEC

Explore this scatter interactively →