GLI2

Across TCGA cell cohorts, GLI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,990 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GLI2-associated GO terms across cancer lineages are RNA localization, Positive regulation of cytoskeleton organization, and Hindgut morphogenesis. Each is linked with GLI2 in more than 11 cancer types. Because this analysis shows association rather than direction, both GLI2-to-partner and partner-to-GLI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA localization grouped by GLI2-low versus GLI2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLI2→partner) and Y-score (partner→GLI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA localization →	+0.086	+1.196	<.001	.001	3	12
LIVER	Positive regulation of cytoskeleton organization →	+0.082	+2.254	<.001	<.001	3	11
LIVER	Hindgut morphogenesis →	+1.383	+3.335	<.001	<.001	3	10
BONE	Nucleic acid transport →	+0.092	+1.146	<.001	.002	3	10
BONE	RNA transport →	+0.092	+1.146	<.001	.002	3	10
BONE	Establishment of RNA localization →	+0.090	+1.166	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,990 associations by consensus.

RNA localization by GLI2 expression — BONE

Explore this box plot interactively →