GLG1

Across TCGA patient cohorts, GLG1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLG1-associated genes across cancer lineages are ATM, Cyclin-D1, and ERK2. Each is linked with GLG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLG1-to-partner and partner-to-GLG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GLG1-low versus GLG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLG1→partner) and Y-score (partner→GLG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.488	-2.401	<.001	.002	3	3
UCEC	Cyclin-D1 →	+0.111	+1.415	.026	.043	3	3
UCEC	ERK2 →	+0.130	+1.906	.029	.014	3	2
UCEC	Rad50 →	-0.166	-1.201	.027	.028	3	2
UCEC	Shc_pY317 →	-0.159	-1.893	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.214	-3.060	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by GLG1 expression — UCEC

Explore this box plot interactively →