GLG1

Across TCGA pan-cancer cohorts, GLG1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GLG1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GLG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GLG1 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where GLG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.425	<.001	12	view →
COAD	Male	All	+0.667	<.001	9	view →
LIHC	Female	II,III,IV	+1.297	<.001	8	view →
STAD	Male	II,III,IV	+1.117	.001	7	view →
BRCA	All	All	−0.402	<.001	6	view →
LUSC	All	All	+0.484	<.001	5	view →
KIRC	Female	III,IV	+0.447	.001	4	view →
LUAD	All	All	+0.282	.002	4	view →
CHOL	Male	All	+2.656	<.001	3	view →
READ	All	III,IV	+0.675	.005	2	view →
UCEC	All	All	−0.655	.003	2	view →
THCA	All	All	−0.223	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GLG1–HNSC

Open the HNSC breakdown →