GLG1

Across TCGA cell cohorts, GLG1 mutation is significantly associated with the RNA expression of many other genes, with 856 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLG1-associated genes across cancer lineages are PPAT, HCN4, and FAM135B. Each is linked with GLG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLG1-to-partner and partner-to-GLG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPAT grouped by GLG1-low versus GLG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLG1→partner) and Y-score (partner→GLG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPAT →	+0.762	+3.714	<.001	<.001	3	2
BLOOD_Leukemia	HCN4 →	+0.032	+4.177	.004	.001	3	2
BLOOD_Lymphoma	FAM135B →	+0.134	+3.693	.002	.009	3	1
BLOOD_Lymphoma	OR56A1 →	+0.030	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP1-4 →	+0.054	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	PRAC2 →	+1.178	+3.954	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 856 associations by consensus.

PPAT by GLG1 expression — LARGE_INTESTINE

Explore this box plot interactively →