GLDC

Across TCGA cell cohorts, GLDC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,429 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GLDC-associated GO terms across cancer lineages are Aminoacyl-tRNA metabolism involved in translational fidelity, Acute inflammatory response, and Regulation of transcription by RNA polymerase I. Each is linked with GLDC in more than 9 cancer types. Because this analysis shows association rather than direction, both GLDC-to-partner and partner-to-GLDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aminoacyl-tRNA metabolism involved in translational fidelity grouped by GLDC-low versus GLDC-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLDC→partner) and Y-score (partner→GLDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.108	+0.998	<.001	.005	3	10
URINARY_TRACT	Acute inflammatory response →	-0.134	-1.712	.002	.003	3	10
BLOOD_Leukemia	Regulation of transcription by RNA polymerase I →	+0.069	+2.002	<.001	<.001	3	10
SOFT_TISSUE	Amino acid activation →	+0.062	+2.053	<.001	<.001	3	9
SOFT_TISSUE	tRNA aminoacylation →	+0.062	+2.053	<.001	<.001	3	9
STOMACH	Positive regulation of monoatomic ion transport →	-0.126	-2.358	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,429 associations by consensus.

Aminoacyl-tRNA metabolism involved in translational fidelity by GLDC expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →