GLDC

Across TCGA pan-cancer cohorts, GLDC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GLDC data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GLDC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GLDC expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRP show a favorable association.

UCEC, UCS, and STAD are the cancer types where GLDC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.888	0.962	<.001	72	view →
UCS	DFS	Median	All	0.366	0.675	.001	56	view →
STAD	DFS	Median	II,III,IV	0.218	0.515	.003	53	view →
SCLC	DFS	Tertile	All	0.612	0.229	<.001	46	view →
KIRP	OS	Median	II,III,IV	0.715	0.354	<.001	43	view →
MESO	OS	Median	All	0.294	0.483	.005	42	view →
KIRC	DFS	Median	All	0.689	0.563	.002	34	view →
SARC	DFS	Tertile	All	0.521	0.672	.005	14	view →
KICH	OS	Median	All	0.756	0.969	.010	13	view →
COAD	OS	Median	III,IV	0.352	0.688	.009	12	view →
LUAD	OS	Median	III,IV	0.350	0.619	.010	11	view →
THCA	OS	Median	II,III,IV	0.929	1.000	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GLDC–UCEC (OS)

Open the UCEC breakdown →