GLDC

Across TCGA cell cohorts, GLDC mutation is significantly associated with the RNA expression of many other genes, with 314 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLDC-associated genes across cancer lineages are OR2J1, CCDC105, and TFDP3. Each is linked with GLDC in more than 1 cancer types. Because this analysis shows association rather than direction, both GLDC-to-partner and partner-to-GLDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2J1 grouped by GLDC-low versus GLDC-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLDC→partner) and Y-score (partner→GLDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2J1 →	+0.006	+5.614	<.001	.002	3	2
PANCREAS	CCDC105 →	+0.013	+5.614	<.001	.002	3	1
PANCREAS	TFDP3 →	+0.013	+5.000	<.001	.006	3	1
PANCREAS	LCE2A →	+0.033	+5.614	<.001	.002	3	1
PANCREAS	XKR4 →	+0.059	+5.000	<.001	.006	3	1
PANCREAS	CACNG3 →	+0.013	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 314 associations by consensus.

OR2J1 by GLDC expression — PANCREAS

Explore this box plot interactively →