GLCCI1

Across TCGA cell cohorts, GLCCI1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GLCCI1-associated genes across cancer lineages are TECRL, OR2B2, and HJV. Each is linked with GLCCI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLCCI1-to-partner and partner-to-GLCCI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TECRL grouped by GLCCI1-low versus GLCCI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLCCI1→partner) and Y-score (partner→GLCCI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1
SKIN	OR2B2 →	+0.027	+3.684	<.001	.006	3	1
SKIN	HJV →	+0.029	+4.054	<.001	.004	3	1
SKIN	KRTAP5-11 →	+0.030	+3.684	<.001	.006	3	1
SKIN	DYTN →	+0.085	+4.217	<.001	.001	3	1
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TECRL by GLCCI1 expression — LARGE_INTESTINE

Explore this box plot interactively →