GLCCI1

Across TCGA pan-cancer cohorts, GLCCI1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GLCCI1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where GLCCI1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GLCCI1 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

BLCA, LUSC, and THCA are the cancer types where GLCCI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GLCCI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.521	<.001	10	view →
LUSC	All	II,III,IV	−1.105	<.001	7	view →
THCA	All	All	−0.444	.004	7	view →
KICH	All	II,III,IV	+1.177	<.001	6	view →
LUAD	Female	II,III,IV	−1.059	<.001	6	view →
UCEC	All	All	+0.409	.021	4	view →
KIRC	Male	All	+0.379	.002	3	view →
ESCA	All	All	+0.613	.011	2	view →
COAD	All	All	−0.338	.014	2	view →
BRCA	All	II,III,IV	+0.229	.035	2	view →
HNSC	All	III,IV	+0.407	.037	1	view →
LIHC	All	All	+0.302	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GLCCI1–BLCA

Open the BLCA breakdown →