Across TCGA patient cohorts, GKN2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,426 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GKN2-associated genes across cancer lineages are MKS1, FOXK2, and DDX42. Each is linked with GKN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GKN2-to-partner and partner-to-GKN2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GKN2→partner) and Y-score (partner→GKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MKS1 →	-0.488	-0.891	<.001	.003	3	2
LSCC	FOXK2 →	-0.527	-0.594	<.001	.001	3	2
PDAC	DDX42 →	-0.412	-0.668	.001	.003	3	2
PDAC	RNU6-865P →	+1.363	+0.582	.002	.005	3	2
LSCC	MIR4463 →	+1.238	+0.629	<.001	<.001	3	2
PDAC	TRBV13 →	+0.845	+0.682	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,426 associations by consensus.

Exploration

GKN2 survival (RNA) · tumor vs normal (RNA) · all GKN2 data types