GKN1

Across TCGA patient cohorts, GKN1 mutation is significantly associated with the RNA expression of many other genes, with 208 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GKN1-associated genes across cancer lineages are GCNT1P2, RNA5SP505, and PRORY. Each is linked with GKN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GKN1-to-partner and partner-to-GKN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCNT1P2 grouped by GKN1-low versus GKN1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GKN1→partner) and Y-score (partner→GKN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GCNT1P2 →	+0.120	+4.973	.001	.009	3	3
LUAD	RNA5SP505 →	+0.410	+5.444	<.001	.002	3	2
UCEC	PRORY →	+0.038	+4.470	<.001	.004	3	2
UCEC	IGHD1-26 →	+0.725	+3.262	<.001	.006	3	2
UCEC	DUTP5 →	+0.171	+3.349	<.001	<.001	3	2
UCEC	RN7SKP286 →	+0.087	+5.060	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 208 associations by consensus.

GCNT1P2 by GKN1 expression — BLCA

Explore this box plot interactively →