GK5

Across TCGA patient cohorts, GK5 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GK5-associated genes across cancer lineages are EGFR_pY1068, EGFR_pY1173, and A-Raf_pS299. Each is linked with GK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GK5-to-partner and partner-to-GK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GK5-low versus GK5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GK5→partner) and Y-score (partner→GK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.234	-2.000	.009	.009	3	1
UCEC	EGFR_pY1173 →	+0.062	+1.306	.031	.036	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.115	.005	.017	3	1
UCEC	FoxM1 →	+0.237	+2.807	.011	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.117	-1.575	.009	.034	3	1
UCEC	HER3_pY1289 →	+0.069	+2.999	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

EGFR_pY1068 by GK5 expression — UCEC

Explore this box plot interactively →