GK5

Across TCGA pan-cancer cohorts, GK5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GK5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GK5 RNA is repressed in tumor relative to normal tissue. In most cancer types GK5 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, LIHC, and CHOL are the cancer types where GK5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GK5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.733	<.001	11	view →
LIHC	Female	II,III,IV	+0.795	<.001	9	view →
CHOL	All	All	+1.894	<.001	5	view →
BLCA	All	All	+0.527	.002	5	view →
ESCA	Female	All	+0.939	.012	4	view →
LUSC	Male	All	+0.580	<.001	4	view →
COAD	Female	All	−0.458	.023	3	view →
PRAD	All	All	+0.534	<.001	2	view →
PAAD	Female	All	+0.250	.013	2	view →
READ	All	III,IV	−0.169	.028	2	view →
LUAD	All	All	+0.265	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GK5–KIRC

Open the KIRC breakdown →