Across TCGA pan-cancer cohorts, GK Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GK data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GK Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GK expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, HNSC, and UCEC are the cancer types where GK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.079	0.777	<.001	36	view →
HNSC	OS	Median	II,III,IV	0.174	0.743	.002	21	view →
UCEC	DFS	Median	All	0.918	0.613	.007	20	view →
LGG	OS	Median	All	0.240	0.830	<.001	12	view →
SKCM	DFS	Median	IV	0.016	0.454	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GK tumor-vs-normal RNA expression · all GK data types