Across TCGA pan-cancer cohorts, GK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GK data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GK expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where GK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.953	0.739	.005	36	view →
LUAD	OS	Median	II,III,IV	0.403	0.825	.015	8	view →
PDAC	DFS	Tertile	III,IV	0.389	0.845	.008	5	view →
GBM	DFS	Quartile	All	0.872	0.574	.020	1	view →
LSCC	OS	Median	III,IV	0.951	0.773	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: GK tumor-vs-normal RNA expression · all GK data types