Across TCGA patient cohorts, GK mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GK-associated genes across cancer lineages are PCNA, Shc_pY317, and eEF2. Each is linked with GK in more than 1 cancer types. Because this analysis shows association rather than direction, both GK-to-partner and partner-to-GK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GK→partner) and Y-score (partner→GK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.210	+1.688	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.124	-1.584	.005	.032	3	2
UCEC	eEF2 →	+0.257	+1.440	.013	.022	3	1
UCEC	EGFR_pY1068 →	-0.207	-2.087	.004	.004	3	1
UCEC	eIF4E →	+0.184	+1.906	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.126	-1.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

GK survival (RNA) · tumor vs normal (RNA) · all GK data types