GK-AS1

Across TCGA pan-cancer cohorts, GK-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GK-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GK-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GK-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and COAD show a favorable association.

BLCA, LGG, and COAD are the cancer types where GK-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.611	0.375	.001	92	view →
LGG	OS	Median	All	0.744	0.863	<.001	48	view →
COAD	OS	Quartile	IV	1.000	0.235	.002	37	view →
UVM	OS	Tertile	III,IV	0.413	0.932	.005	33	view →
SKCM	OS	Quartile	III,IV	0.486	0.246	.004	32	view →
READ	OS	Quartile	III,IV	1.000	0.786	.004	27	view →
THCA	OS	Median	II,III,IV	0.902	0.987	.002	25	view →
UCS	DFS	Tertile	IV	0.981	0.401	.024	24	view →
MESO	DFS	Tertile	All	0.318	0.669	.012	24	view →
PCPG	DFS	Median	All	0.693	0.952	.004	23	view →
KIRP	DFS	Median	II,III,IV	0.873	0.277	.004	22	view →
ESCA	OS	Median	All	0.449	1.000	.011	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GK-AS1–BLCA (OS)

Open the BLCA breakdown →