GK-AS1

Across TCGA pan-cancer cohorts, GK-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GK-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GK-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GK-AS1 is over-expressed in tumor, although a few such as LUSC and LIHC show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where GK-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GK-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.778	<.001	8	view →
KIRC	All	II,III,IV	+0.416	<.001	8	view →
KIRP	All	All	+0.369	.004	6	view →
LUSC	All	All	−0.501	<.001	5	view →
STAD	Female	All	+0.838	.002	4	view →
KICH	Male	All	+0.360	.003	4	view →
READ	All	All	+1.032	.004	3	view →
BRCA	All	All	+0.149	.045	3	view →
LIHC	Male	All	−0.382	.019	2	view →
ESCA	All	All	+1.268	.015	1	view →
HNSC	Male	III,IV	+0.286	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GK-AS1–COAD

Open the COAD breakdown →