GJC1

Across TCGA cell cohorts, GJC1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GJC1-associated genes across cancer lineages are MTRNR2L6, ADAM30, and TRIM42. Each is linked with GJC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJC1-to-partner and partner-to-GJC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by GJC1-low versus GJC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJC1→partner) and Y-score (partner→GJC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MTRNR2L6 →	+0.101	+5.269	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ADAM30 →	+0.011	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	TRIM42 →	+0.006	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.025	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR4F15 →	+0.006	+4.947	.001	.001	3	1
LUNG_NSCLC_LUAD	OR10G2 →	+0.020	+4.212	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MTRNR2L6 by GJC1 expression — BLOOD_Leukemia

Explore this box plot interactively →