Across TCGA patient cohorts, GJB5 protein abundance is significantly associated with the RNA expression of many other genes, with 776 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GJB5-associated genes across cancer lineages are MAST3, GZMH, and MYLK2. Each is linked with GJB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB5-to-partner and partner-to-GJB5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB5→partner) and Y-score (partner→GJB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAST3 →	-0.776	-0.792	<.001	.006	3	2
LSCC	GZMH →	-1.118	-0.959	<.001	.002	3	1
LSCC	MYLK2 →	-0.318	-0.960	.004	<.001	3	1
LSCC	RNF125 →	-0.537	-0.989	<.001	<.001	3	1
LSCC	NAGPA →	-0.658	-1.126	.005	<.001	3	1
LSCC	NISCH →	-0.432	-0.867	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

Exploration

GJB5 survival (RNA) · tumor vs normal (RNA) · all GJB5 data types