GJB3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GJB3 mutation is significantly associated with the RNA expression of many other genes, with 1,331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB3-associated genes across cancer lineages are RNA5SP308, RNA5SP241, and RNA5SP362. Each is linked with GJB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB3-to-partner and partner-to-GJB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB3→partner) and Y-score (partner→GJB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCRNA5SP308 →+0.505+6.164.001<.00132
CESCRNA5SP241 →+0.327+4.969<.001.00432
COADRNA5SP362 →+0.362+5.734<.001<.00132
UCECC4orf33 →+0.415+3.362.009.00532
UCECAP1S3 →+0.695+3.807<.001<.00132
UCECUSP12 →+0.500+2.087.002.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

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