GJB2

Across TCGA cell cohorts, GJB2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GJB2-associated genes across cancer lineages are OR5W2, TBC1D3, and FAM205A. Each is linked with GJB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB2-to-partner and partner-to-GJB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5W2 grouped by GJB2-low versus GJB2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB2→partner) and Y-score (partner→GJB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5W2 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.030	+4.614	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR5W2 by GJB2 expression — SKIN

Explore this box plot interactively →