GJB1

Across TCGA patient cohorts, GJB1 mutation is significantly associated with the RNA expression of many other genes, with 2,810 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJB1-associated genes across cancer lineages are KLRC4, RNY4P27, and MIR193A. Each is linked with GJB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJB1-to-partner and partner-to-GJB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRC4 grouped by GJB1-low versus GJB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJB1→partner) and Y-score (partner→GJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLRC4 →	+0.199	+2.722	<.001	<.001	3	2
UCEC	RNY4P27 →	+0.140	+3.132	.001	.005	3	2
UCEC	MIR193A →	+0.571	+2.921	.003	<.001	3	2
UCEC	RNA5SP164 →	+0.101	+4.060	<.001	.006	3	2
UCEC	RNA5SP422 →	+0.844	+2.019	<.001	.005	3	2
SCLC	ZNF479 →	+0.139	+5.189	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,810 associations by consensus.

KLRC4 by GJB1 expression — UCEC

Explore this box plot interactively →