GJA8

Across TCGA patient cohorts, GJA8 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA8-associated genes across cancer lineages are Ku80, mTOR_pS2448, and Caspase-7-cleavedD198. Each is linked with GJA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJA8-to-partner and partner-to-GJA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by GJA8-low versus GJA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA8→partner) and Y-score (partner→GJA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.282	+1.750	<.001	.004	3	3
COAD	mTOR_pS2448 →	-0.176	-3.152	.023	.017	3	3
UCEC	Caspase-7-cleavedD198 →	+0.509	+1.827	.013	.015	3	3
UCEC	N-Ras →	-0.108	-1.847	.008	.049	3	2
UCEC	p70-S6K_pT389 →	-0.167	-1.700	.011	.040	3	2
UCEC	P-Cadherin →	-0.146	-2.222	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Ku80 by GJA8 expression — UCEC

Explore this box plot interactively →