GJA8

Across TCGA pan-cancer cohorts, GJA8 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated GJA8 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GJA8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GJA8 expression acts as an unfavorable survival marker, although some lineages such as ESCA and STAD show a favorable association.

ACC, THYM, and MESO are the cancer types where GJA8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.146	0.619	<.001	60	view →
THYM	OS	Tertile	II,III,IV	0.559	0.980	<.001	42	view →
MESO	OS	Tertile	All	0.367	0.568	.021	36	view →
SCLC	OS	Tertile	II,III,IV	0.164	0.819	<.001	36	view →
UCEC	DFS	Tertile	All	0.581	0.686	.001	34	view →
KICH	OS	Tertile	II,III,IV	0.155	0.880	<.001	30	view →
COAD	OS	Tertile	IV	0.197	0.571	.024	30	view →
ESCA	DFS	Tertile	IV	0.704	0.249	.013	24	view →
LUAD	DFS	Tertile	IV	0.333	0.671	.048	18	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	18	view →
DLBC	DFS	Tertile	IV	0.120	0.683	.001	18	view →
STAD	DFS	Quartile	IV	0.670	0.208	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GJA8–ACC (DFS)

Open the ACC breakdown →