GJA8

Across TCGA cell cohorts, GJA8 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GJA8-associated genes across cancer lineages are CPLX4, SCYGR1, and SLC25A31. Each is linked with GJA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA8-to-partner and partner-to-GJA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by GJA8-low versus GJA8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA8→partner) and Y-score (partner→GJA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.021	+3.766	.006	.004	3	2
LARGE_INTESTINE	SCYGR1 →	+0.111	+4.022	<.001	.006	3	2
CNS	SLC25A31 →	+0.029	+4.273	<.001	.002	3	2
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1
SOFT_TISSUE	FCAR →	+0.070	+4.222	<.001	.007	3	1
SOFT_TISSUE	LCE6A →	+0.030	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

CPLX4 by GJA8 expression — LARGE_INTESTINE

Explore this box plot interactively →