GJA3

Across TCGA patient cohorts, GJA3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA3-associated genes across cancer lineages are ERK2, Lck, and Caspase-7-cleavedD198. Each is linked with GJA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA3-to-partner and partner-to-GJA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GJA3-low versus GJA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA3→partner) and Y-score (partner→GJA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.201	+2.169	.005	.003	3	2
UCEC	Lck →	+0.265	+2.000	<.001	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+1.101	+2.662	<.001	<.001	3	2
UCEC	eIF4E →	+0.223	+2.169	.004	.003	2	2
UCEC	GAPDH →	+0.547	+1.765	.006	.014	3	1
UCEC	Heregulin →	-0.113	-2.446	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ERK2 by GJA3 expression — UCEC

Explore this box plot interactively →