GJA3

Across TCGA pan-cancer cohorts, GJA3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GJA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GJA3 RNA is repressed in tumor relative to normal tissue. In most cancer types GJA3 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and COAD are the cancer types where GJA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GJA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−1.524	<.001	11	view →
KIRC	Male	All	−0.866	<.001	11	view →
COAD	All	II,III,IV	+0.523	<.001	10	view →
LUSC	Male	II,III,IV	+1.920	<.001	8	view →
HNSC	Male	All	+1.117	<.001	8	view →
BRCA	Female	II,III,IV	+0.248	<.001	6	view →
KICH	Female	All	−1.134	<.001	5	view →
LUAD	All	All	+0.166	.003	3	view →
PRAD	All	All	+0.385	<.001	2	view →
BLCA	All	All	+0.375	.042	2	view →
LIHC	Female	All	+0.074	.029	2	view →
CHOL	All	All	+0.285	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GJA3–KIRP

Open the KIRP breakdown →