GJA3

Across TCGA cell cohorts, GJA3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GJA3-associated genes across cancer lineages are OR6B3, GOLGA6L1, and CABP5. Each is linked with GJA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA3-to-partner and partner-to-GJA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B3 grouped by GJA3-low versus GJA3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA3→partner) and Y-score (partner→GJA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6B3 →	+0.081	+4.437	<.001	.004	3	1
SKIN	GOLGA6L1 →	+0.010	+3.684	<.001	.006	3	1
LUNG_NSCLC_LUAD	CABP5 →	+0.233	+2.896	<.001	.008	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.017	+3.472	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR3A3 →	+0.065	+2.980	<.001	.007	3	1
LUNG_NSCLC_LUAD	WFDC5 →	+0.116	+3.958	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR6B3 by GJA3 expression — SKIN

Explore this box plot interactively →