GJA3

Across TCGA cell cohorts, GJA3 mutation is significantly associated with the mutation status of many other genes, with 1,729 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GJA3-associated genes across cancer lineages are ZNF536, ZFP57, and SALL4. Each is linked with GJA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both GJA3-to-partner and partner-to-GJA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF536 grouped by GJA3-low versus GJA3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA3→partner) and Y-score (partner→GJA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF536 →	+2.602	+3.528	.003	.003	1	4
OVARY	ZFP57 →	+5.415	+5.415	.004	.004	1	4
LUNG_NSCLC_LUAD	SALL4 →	+4.063	+3.584	.003	.003	1	3
LUNG_NSCLC_LUAD	UBR2 →	+4.063	+3.584	.003	.003	1	3
OVARY	PHKB →	+4.415	+4.977	.007	.007	1	3
OVARY	MORC1 →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,729 associations by consensus.

ZNF536 by GJA3 expression — SKIN

Explore this box plot interactively →