GJA10

Across TCGA pan-cancer cohorts, GJA10 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GJA10 data layer compared with 18 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GJA10 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GJA10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUAD, and LGG are the cancer types where GJA10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.621	.003	36	view →
LUAD	DFS	Median	All	0.176	0.659	<.001	17	view →
LGG	OS	Median	All	0.204	0.810	<.001	12	view →
SKCM	OS	Median	II,III,IV	0.732	0.343	.004	11	view →
BRCA	OS	Median	All	0.780	0.924	.020	8	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GJA10–UCEC (DFS)

Open the UCEC breakdown →