Across TCGA pan-cancer cohorts, GJA10 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of GJA10’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where GJA10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GJA10 is over-expressed in tumor.
LIHC and LUAD are the cancer types where GJA10 tumor–normal differential expression is most reproducible.