GJA1

Across TCGA pan-cancer cohorts, GJA1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GJA1 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GJA1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GJA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

UCEC, LIHC, and ESCA are the cancer types where GJA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.922	0.437	.028	14	view →
LIHC	DFS	Median	All	0.241	0.549	.006	9	view →
ESCA	OS	Median	III,IV	0.136	0.573	.023	6	view →
UCS	DFS	Median	All	1.000	0.394	.045	2	view →
LUSC	DFS	Median	All	0.323	0.714	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GJA1–UCEC (DFS)

Open the UCEC breakdown →