GJA1

Across TCGA pan-cancer cohorts, GJA1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GJA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GJA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GJA1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where GJA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GJA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.636	<.001	12	view →
KIRC	Male	All	+2.015	<.001	11	view →
LUAD	All	All	−1.009	<.001	10	view →
THCA	Female	II,III,IV	−1.259	<.001	9	view →
LIHC	Female	II,III,IV	+1.781	<.001	8	view →
KICH	All	III,IV	−1.801	.001	7	view →
CHOL	All	All	+2.360	.002	3	view →
PRAD	All	All	−1.237	<.001	2	view →
READ	Female	All	−0.686	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GJA1–HNSC

Open the HNSC breakdown →