GJA1

Across TCGA pan-cancer cohorts, GJA1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GJA1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher GJA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GJA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where GJA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.524	0.954	<.001	14	view →
HNSC	DFS	Quartile	All	0.756	0.491	.014	13	view →
GBM	OS	Median	All	0.221	0.593	.001	13	view →
CCRCC	DFS	Tertile	IV	1.000	0.213	.024	12	view →
UCEC	DFS	Tertile	All	0.780	0.973	.019	4	view →
LSCC	DFS	Tertile	III,IV	0.979	0.503	.015	4	view →
PDAC	DFS	Tertile	All	0.632	0.898	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GJA1–LUAD (OS)

Open the LUAD breakdown →