GJA1

Across TCGA patient cohorts, GJA1 mutation is significantly associated with the RNA expression of many other genes, with 2,374 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA1-associated genes across cancer lineages are RNU6-709P, TXNL4B, and UFD1. Each is linked with GJA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJA1-to-partner and partner-to-GJA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by GJA1-low versus GJA1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA1→partner) and Y-score (partner→GJA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-709P →	+0.192	+5.852	<.001	<.001	3	3
UCEC	TXNL4B →	+0.525	+2.595	<.001	<.001	3	3
UCEC	UFD1 →	+0.347	+1.860	<.001	.002	3	3
UCEC	BUB3 →	+0.482	+2.190	<.001	.008	3	3
UCEC	CCNB2 →	+0.749	+3.031	<.001	<.001	3	3
UCEC	MELK →	+0.698	+3.098	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,374 associations by consensus.

RNU6-709P by GJA1 expression — CESC

Explore this box plot interactively →