GJA1

Across TCGA patient cohorts, GJA1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GJA1-associated genes across cancer lineages are Notch1, eIF4E, and A-Raf_pS299. Each is linked with GJA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GJA1-to-partner and partner-to-GJA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GJA1-low versus GJA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA1→partner) and Y-score (partner→GJA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.172	+2.128	<.001	.009	3	3
UCEC	eIF4E →	+0.248	+4.000	<.001	<.001	2	3
COAD	A-Raf_pS299 →	-0.219	-2.313	.004	.035	3	2
COAD	FoxM1 →	+0.396	+2.330	.013	.020	3	2
UCEC	INPP4B →	-0.392	-2.999	<.001	<.001	3	2
COAD	JNK_pT183_Y185 →	-0.259	-3.000	.027	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Notch1 by GJA1 expression — UCEC

Explore this box plot interactively →