GJA1

Across TCGA cell cohorts, GJA1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GJA1-associated genes across cancer lineages are MAGEB4, MBD3L5, and SLC5A7. Each is linked with GJA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GJA1-to-partner and partner-to-GJA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by GJA1-low versus GJA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GJA1→partner) and Y-score (partner→GJA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAGEB4 →	+0.005	+4.643	<.001	.004	3	2
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SLC5A7 →	+0.027	+2.925	<.001	.007	3	1
LARGE_INTESTINE	VCY1B →	+0.685	+2.936	.002	.007	3	1
LARGE_INTESTINE	VCY →	+0.531	+2.994	.001	.006	3	1
LARGE_INTESTINE	C1orf189 →	+0.133	+3.376	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MAGEB4 by GJA1 expression — LUNG_SCLC

Explore this box plot interactively →