GIT2

Across TCGA cell cohorts, GIT2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GIT2-associated genes across cancer lineages are TMSB4Y, OR10K2, and OR6S1. Each is linked with GIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIT2-to-partner and partner-to-GIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by GIT2-low versus GIT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIT2→partner) and Y-score (partner→GIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMSB4Y →	+1.715	+3.556	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10K2 →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR6S1 →	+0.042	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	AGBL1 →	+0.027	+4.544	<.001	.003	3	1
BREAST	KRTAP12-1 →	+0.104	+5.169	<.001	.005	3	1
BREAST	POTEB →	+0.026	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TMSB4Y by GIT2 expression — LARGE_INTESTINE

Explore this box plot interactively →